Nitrofurantoin-induced lung- and hepatotoxicity.

Author(s): Koulaouzidis A, Bhat S, Moschos J, Tan C, De Ramon A

Affiliation(s): Department of Gastroenterology, Warrington Hospital, Warrington. akoulaouzidis@hotmail.com

Publication date & source: 2007-04, Ann Hepatol., 6(2):119-21.

Publication type: Case Reports

We present the case of a patient referred to the gastroenterology service for investigation of abnormal liver function tests. She had been taking nitrofurantoin for 16 months as prophylaxis against urinary tract infections. CT scan showed evidence of lung pneumonitis and low attenuation in the liver parenchyma. Nitrofurantoin-induced pneumonitis and hepatotoxicity was diagnosed. The patient responded both clinically and biochemically to withdrawal of nitrofurantoin. This combination of adverse reaction to nitrofurantoin is rare.