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The efficacy of nebulized salbutamol, magnesium sulfate, and salbutamol/magnesium sulfate combination in moderate bronchiolitis.

Author(s): Kose M(1), Ozturk MA, Poyrazoğlu H, Elmas T, Ekinci D, Tubas F, Kurt T, Goktas MA.

Affiliation(s): Author information: (1)Department of Pediatric Pulmonology, Erciyes University Faculty of Medicine, Pediatric Pulmonology Unit, Kayseri, 38000, Turkey, mhmtkose@yahoo.com.

Publication date & source: 2014, Eur J Pediatr. , 173(9):1157-60

The aim of this paper is to compare the effect of nebulized magnesium sulfate to nebulized salbutamol and salbutamol/magnesium sulfate on successful discharge from the emergency department. A total of 56 infants were included in this double-blinded, prospective study. Infants were grouped according to the nebulized treatment they received: group 1-salbutamol/normal saline, group 2-magnesium sulfate and normal saline, and group 3-salbutamol plus magnesium sulfate. Heart beat, bronchiolitis, clinical severity scores (CSS), and oxygen saturation of the patients were determined before and after nebulization (0, 1, 4 h). The patients were monitored for adverse reactions. Post-treatment mean CSS results were significantly lower than pre-treatment scores in all groups at 4 h with no significant difference within groups. CSS scores were lower in the salbutamol/magnesium sulfate group when compared with the magnesium sulfate and salbutamol groups (3.4 (2.4-4.3), 4.7 (3.8-5.7), 4.0 (3.2-4.3)). CSS were significantly lower than those from the magnesium sulfate group.CONCLUSION: Nebulized magnesium sulfate plus salbutamol may have additive effects for improving the short-term CSS.

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