[The comparison of tianeptine and carbamazepine in benzodiazepines withdrawal symptoms]

Author(s): Kornowski J

Affiliation(s): Szpital dla Nerwowo i Psychicznie Chorych w Starogardzie Gdanskim.

Publication date & source: 2002-11, Psychiatr Pol., 36(6 Suppl):311-8.

Publication type: Clinical Trial; Randomized Controlled Trial

Dealing with benzodiazepine dependent creates as serious clinical problem that requires knowledge and experience. Abrupt discontinuation of benzodiazepines, particularly those with short half-life is not advised to avoid severe withdrawal syndrome. Reports from literature suggest use of carbamazepine and recently tianeptine as substances useful in treatment of benzodiazepine dependence. This paper presents a double-blind trial in which both, carbamazepine and tianeptine were used in treatment of benzodiazepiene withdrawal syndrome. Patient mental state was evaluated by using questionnaire SCL-90, Beck Depression Inventory and specifically designed questionnaire assessing severity of symptoms following benzodiazepine withdrawal. It appears from this study that both drugs (carbamazepine and tianeptine) are comparable, safe and efficient in treating benzodiazepine withdrawal symptoms.