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24-h Intraocular pressure control with evening-dosed travoprost/timolol, compared with latanoprost/timolol, fixed combinations in exfoliative glaucoma.

Author(s): Konstas AG, Mikropoulos DG, Embeslidis TA, Dimopoulos AT, Papanastasiou A, Haidich AB, Stewart WC

Affiliation(s): Glaucoma Unit, Department of Ophthalmology, First University, Thessaloniki, Greece.

Publication date & source: 2010-10, Eye (Lond)., 24(10):1606-13. Epub 2010 Jul 23.

Publication type: Randomized Controlled Trial

PURPOSE: To evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC) vslatanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma (XFG). DESIGN: A prospective, single-masked, crossover, active-controlled, randomized 24-h comparison. METHODS: After up to a 6-week medicine-free period, XFG patients were randomized to either TTFC or LTFC for 3 months, dosed each evening, and then changed to the opposite treatment for another 3 months. At the end of the washout, and both treatment periods, a 24-h intraocular pressure (IOP) curve was measured. RESULTS: In total, 40 patients completed the study. The TTFC group showed a lower mean absolute 24-h IOP (18.7+/-2.6 vs 19.6+/-2.6 mm Hg, P<0.001), maximum IOP (20.5+/-2.6 vs 21.5+/-2.6 mm Hg, P<0.001) and 24-h IOP range (3.4+/-1.3 vs 4.1+/-1.6 mm Hg, P=0.01). At individual time points, TTFC showed reduced IOPs compared with LTFC, after a Bonferroni correction, at 1000, 1800, and 2200 hours (P</=0.04). No statistical differences existed at hours: 0600, 1400, and 0200 (P>/=0.05) and for the minimum IOP (P=0.09). CONCLUSIONS: This study suggests that evening-dosed TTFC may provide greater 24-h IOP reduction, primarily at the 1800 hours time point, compared with LTFC in XFG.

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