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A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy.

Author(s): Kohler JA, Imeson J, Ellershaw C, Lie SO

Affiliation(s): Child Health, Southampton General Hospital, Southampton, United Kingdom.

Publication date & source: 2000-11, Br J Cancer., 83(9):1124-7.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid. Copyright 2000 Cancer Research Campaign.

Page last updated: 2006-01-31

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