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Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs.

Author(s): Ko JC, Payton ME, White AG, Galloway DS, Inoue T

Affiliation(s): Department of Veterinary Clinical Sciences, College of Arts and Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA.

Publication date & source: 2006-01, J Am Anim Hosp Assoc., 42(1):18-27.

Publication type: Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

This crossover study tested the hypothesis that both diazepam and microdose medetomidine would comparably reduce the amount of propofol required to induce sedation. Four different medications, namely high-dose diazepam (0.4 mg/kg intravenously [IV]), low-dose diazepam (0.2 mg/kg IV), medetomidine (1 mug/kg IV), and placebo (0.5 mL physiological saline IV) were followed by propofol (8 mg/kg IV) titrated to a point where intubation could be performed. The effects of medetomidine were comparable to the effects of high-dose diazepam and significantly better than the effects of low-dose diazepam or placebo. Dogs in all treatment groups had transient hypoxemia, and induction and recovery qualities were similar.

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