Hemispheric-synchronisation during anaesthesia: a double-blind randomised trial
using audiotapes for intra-operative nociception control.
Author(s): Kliempt P, Ruta D, Ogston S, Landeck A, Martay K.
Affiliation(s): Department of Epidemiology, Ninewells Hospital, Dundee DD1 9SY, UK.
Publication date & source: 1999, Anaesthesia. , 54(8):769-73
The possible antinociceptive effect of hemispheric-synchronised sounds, classical
music and blank tape were investigated in patients undergoing surgery under
general anaesthesia. The study was performed on 76 patients, ASA 1 or 2, aged
18-75 years using a double-blind randomised design. Each of the three tapes was
allocated to the patients according to a computer-generated random number table.
General anaesthesia was standardised and consisted of propofol, nitrous oxide
66%/oxygen 33%, isoflurane and fentanyl. Patients breathed spontaneously through
a laryngeal mask and the end-tidal isoflurane concentration was maintained near
to its minimum alveolar concentration value of 1.2%. Fentanyl was given
intravenously sufficient to keep the intra-operative heart rate and arterial
blood pressure within 20% of pre-operative baseline values and the fentanyl
requirements were used as a measure of nociception control. Patients to whom
hemispheric-synchronised sounds were played under general anaesthesia required
significantly less fentanyl compared with patients listening to classical music
or blank tape (mean values: 28 microgram, 124 microgram and 126 microg,
respectively) (p < 0.001). This difference remained significant when regression
analysis was used to control for the effects of age and sex.
|