Effect of dofetillide on the pharmacokinetics of digoxin.

Author(s): Kleinermans D, Nichols DJ, Dalrymple I

Affiliation(s): Pfizer Clinical Research Unit, H pital Erasme, Brussels, Belgium.

Publication date & source: 2001-01-15, Am J Cardiol., 87(2):248-50, A9-10.

Publication type: Clinical Trial; Randomized Controlled Trial

The effect of dofetilide on the steady-state pharmacokinetics of digoxin was evaluated in a randomized, double-blind study. Five days of dofetilide treatment did not significantly affect steady-state pharmacokinetic variables of digoxin compared with placebo; therefore, the use of dofetilide does not necessitate an adjustment in digoxin dose to maintain therapeutic digoxin levels.