[Treatment with low-dose vaginal estradiol in post-menopausal women. A double-blind controlled trial]

Author(s): Kjaergaard B, Walter S, Knudsen A, Johansen B, Barlebo H

Affiliation(s): Aalborg Sygehus, urologisk afdeling, gynaekologisk afdeling og patologisk institut.

Publication date & source: 1990-03-05, Ugeskr Laeger., 152(10):658-9.

Publication type: Clinical Trial; Randomized Controlled Trial

Twenty-three postmenopausal women with recurrent cystitis were allorted at random to treatment for five months with local oestrogen in the vagina or placebo treatment with the object of assessing the local effect on the vaginal epithelium and on the tendency to recurrent cystitis. The therapeutic group and the placebo group were entirely comparable prior to treatment. In the therapeutic group, the oestrogen index in vaginal scrapings was significantly higher after treatment than in the placebo group (p less than 0.01). The number of positive urine cultures and the patients/satisfaction with treatment wee not significantly different in the two groups.