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Update on the everolimus-eluting coronary stent system: results and implications from the SPIRIT clinical trial program.

Author(s): Kirchner RM, Abbott JD

Affiliation(s): Department of Cardiology, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA.

Publication date & source: 2009, Vasc Health Risk Manag., 5:1089-97. Epub 2009 Dec 29.

Publication type: Review

Drug-eluting stents (DES) have had a major impact in interventional cardiology. Compared to bare metal stents, they significantly reduce restenosis and the need for target vessel revascularization. Four DES are available in the US, the first-generation sirolimus-eluting (Cypher((R))) and paclitaxel-eluting (Taxus((R))) stents and later approved second-generation everolimus-eluting (Xience V((R))) and zotarolimus-eluting (Endeavor((R))) stents. The Xience V stent was approved on the basis of clinical efficacy and safety data from 3 studies in the SPIRIT clinical trial program. Within this trial series, the Xience V was superior to its bare metal stent counterpart, the Vision(R) stent, and noninferior to the paclitaxel-eluting stent for target vessel failure at 9 months. This review provides a comprehensive assessment of the data derived from both the pre- and post-approval randomized controlled trials and registry studies of Xience V that comprise the SPIRIT clinical trial program including recently published mid-term outcomes. The implications of the results in terms of interventional practice will be discussed.

Page last updated: 2010-10-05

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