Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients.

Author(s): Kinnunen O, Winblad I, Koistinen P, Salokannel J

Affiliation(s): Kontinkangas Hospital of Oulu, Finland.

Publication date & source: 1993-10, Pharmacology., 47 Suppl 1:253-5.

Publication type: Clinical Trial; Randomized Controlled Trial

Thirty geriatric long-stay patients aged 65-94 years (mean 81.8) participated in the trial the aim of which was to examine bulk laxative plus senna (Agiolax) in the treatment of chronic constipation using lactulose (Levolac) as a reference medicine. Bulk laxative plus senna (daily doses 14.8 g) produced more frequent (p < 0.05) bowel habits (4.5 vs. 2.2-1.9/week) than lactulose (daily doses 20.1 g). Both laxatives proved to be safe to use. Our study indicated bulk laxative plus senna to be more efficient in treating constipation in geriatric long-stay patients.