Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a
double-blind randomized controlled trial.
Author(s): Kim YH(1), Namgung J, Lim CH.
Affiliation(s): Author information:
(1)Department of Anaesthesia and Pain Medicine, Ansan Hospital, Korea University
College of Medicine, Ansan, Republic of Korea.
Publication date & source: 2014, J Int Med Res. , 42(2):360-7
OBJECTIVES: To investigate the efficacy of pretreatment with cisatracurium for
prevention of pain associated with propofol injection, and compare its efficacy
with that of lidocaine.
METHODS: Patients undergoing general anaesthesia were randomized to receive
normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or
0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal
vein of the hand with venous occlusion for 30 s, followed by propofol (0.5
mg/kg). Pain was evaluated using a four-point scale.
RESULTS: The incidence and severity of pain was significantly lower in the
lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg
cisatracurium groups (n = 50/group). There was no significant difference between
the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity
of pain.
CONCLUSIONS: 0.15 mg/kg cisatracurium effectively decreases the incidence and
severity of pain induced by propofol injection without any significant
complications.
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