Pregabalin reduces post-operative pain after mastectomy: a double-blind,
randomized, placebo-controlled study.
Author(s): Kim SY, Song JW, Park B, Park S, An YJ, Shim YH.
Affiliation(s): Department of Anesthesiology and Pain Medicine, Yonsei University College of
Medicine, Seoul, Korea.
Publication date & source: 2011, Acta Anaesthesiol Scand. , 55(3):290-6
BACKGROUND: Pregabalin is used for the treatment of neuropathic pain and has
shown analgesic efficacy in post-operative pain. The aim of this randomized,
double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00938548) was
to investigate the efficacy and safety of pregabalin for reducing post-operative
pain in patients after mastectomy.
METHODS: Eighty-four women scheduled for elective mastectomy were randomly
assigned to groups that received either pregabalin (75 mg) or placebo, 1 h before
surgery and 12 h after the initial dose. Assessments of pain [verbal numerical
rating scale (VNRS), at rest and with arm abduction] and side effects were
performed at 1, 6, 24 and 48 h post-operatively. After discharge from the
hospital, pain was assessed by telephone interview at post-operative 1 week and 1
RESULTS: VNRS scores for pain at rest were lower in the pregabalin group (n=42)
than the placebo group (n=42) at 1, 24 and 48 h post-operatively (P<0.05). VNRS
scores for pain with arm abduction were lower in the pregabalin group (n=42) than
the placebo group (n=42) at 1 and 24 h, and 1 week post-operatively (P<0.05).
Incidences of side effects such as nausea and vomiting, headache, dizziness and
blurred vision were similar in both groups.
CONCLUSION: Perioperative administration of pregabalin for a single day (75 mg
twice daily) was easy, safe and effective in reducing post-operative pain in
patients undergoing mastectomy.