Treatment of Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli by oral administration of praziquantel in combination with cimetidine.

Author(s): Kim KH, Lee EH, Kwon SR, Cho JB

Affiliation(s): Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, Pusan, Korea. khkim@dolphin.pknu.ac.kr

Publication date & source: 2001-03-09, Dis Aquat Organ., 44(2):133-6.

Publication type: Clinical Trial; Randomized Controlled Trial

The effect of cimetidine on the treatment efficacy of praziquantel against Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli was investigated. Juvenile rockfish were divided into 7 groups, and orally administered praziquantel alone (50, 100 and 200 mg kg(-1) body wt, BW) or in combination with cimetidine at a dose of 200 mg kg(-1) BW for each praziquantel dose. The fish in the control group were administered only saline. The results clearly showed that coadministration of cimetidine with praziquantel led to a significantly increased treatment efficacy of the latter drug, and consequently would lead to a lowering of the total dose of praziquantel, and a reduction in the administration times and costs for the treatment of M. sebastis infestation in cultured rockfish.