Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate.

Author(s): Kim JO, Choi JY, Park JK, Kim JH, Jin SG, Chang SW, Li DX, Hwang MR, Woo JS, Kim JA, Lyoo WS, Yong CS, Choi HG

Affiliation(s): Dong-A Pharm. Co., Ltd., Yongin-Si, Kyunggi-Do 449-905, South Korea.

Publication date & source: 2008-12, Biol Pharm Bull., 31(12):2277-82.

Publication type: Research Support, Non-U.S. Gov't

To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freeze-thawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA). The physicochemical properties such as swelling ratio, tensile strength and elongation of hydrogels were evaluated. The drug release from this clindamycin-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were then performed. Increased SA concentration decreased the gelation %, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of clindamycin. This hydrogel improved the healing rate of artificial wounds in rats. Thus, a clindamycin-loaded wound dressing with PVA and SA hydrogel should be a candidate for wound care.