Postoperative maxillary sinus mucocoele: risk factors for restenosis after
surgery and preventive effects of mytomycin-C.
Author(s): Kim HY(1), Dhong HJ, Min JY, Jung YG, Park SH, Chung SK.
Affiliation(s): Author information:
(1)Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Publication date & source: 2009, Rhinology. , 47(1):79-84
OBJECTIVE: To evaluate the clinical factors associated with restenosis after the
surgery for treating postoperative maxillary sinus mucocoele and the preventive
effect of topically applied mytomycin-C (MMC) on the restenosis.
METHODS: This double-blinded randomized controlled prospective study included 38
cases of postoperative maxillary sinus mucocoeles. The patients underwent
inferior meatal antrostomy with or without Caldwell-Luc operation, and
cotton-pledgets soaked with MMC or normal saline were applied to the antrostomy
sites for 5 minutes. The degree of narrowing of the opening and its correlation
with the preoperative characteristics, including age, gender, allergy, presence
of polyps, interval between previous surgery and computed tomography findings
were evaluated.
RESULTS: Three months after the surgery, the openings were patent in 24 cases,
narrowed in 5 cases and stenotic in 9 cases. MMC application, septation of
mucocoele and concurrent inflammation at the lesion side all had a significant
effect on stenosis of the antrostomy site at 3 months after the surgery (p <
0.05, Chi-square test).
CONCLUSIONS: MMC has a favorable effect in preventing narrowing of the opening
after surgery for maxillary sinus mucocoeles. The presence of septa in the
mucocoeles or concurrent inflammation in the ipsilateral sinuses has an effect to
promote restenosis.
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