Ocular penetration of moxifloxacin 0.5% and gatifloxacin 0.3% ophthalmic solutions into the aqueous humor following topical administration prior to routine cataract surgery.

Author(s): Kim DH, Stark WJ, O'Brien TP

Affiliation(s): Anterior Segment and Cataract/Refractive Service at the Wilmer Eye Institute, The Johns Hopkins Hospital, Baltimore, MD 21287-0682, USA.

Publication date & source: 2005-01, Curr Med Res Opin., 21(1):93-4.

Publication type: Clinical Trial; Randomized Controlled Trial

A prospective, double-masked, randomized, parallel-group study (n = 25) was conducted to examine the ocular penetration of moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% solution into the aqueous humor following topical administration prior to routine cataract surgery. One drop of antibiotic was instilled every 10 min for four doses beginning 1 h prior to surgery. Preliminary results showed aqueous humor concentrations for moxifloxacin that were significantly greater (p < 0.01) than those for gatifloxacin.