Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne
vulgaris.
Author(s): Khodaeiani E(1), Fouladi RF, Amirnia M, Saeidi M, Karimi ER.
Affiliation(s): Author information:
(1)Department of Dermatology, Sina Hospital, Tabriz, Iran.
Publication date & source: 2013, Int J Dermatol. , 52(8):999-1004
Nicotinamide and clindamycin gels are two popular topical medications for acne
vulgaris. This study aimed to compare efficacy of the topical 4% nicotinamide and
1% clindamycin gels in these patients. In this randomized, double-blind clinical
trial, patients with moderate inflammatory facial acne vulgaris were randomly
allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin
gels (n = 40) twice daily. In each group, they were further categorized in two
subgroups with oily and non-oily types of facial skin. The Cook's acne grade was
determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased
from an average of 5.93 ± 0.83 at baseline to 4.03 ± 1.33 at week 4 and
2.08 ± 1.59 at week 8 in nicotinamide receivers, and from an average of
5.70 ± 0.94 at baseline to 3.85 ± 1.66 at week 4 and 2.03 ± 1.53 at week 8 in the
clindamycin group (within-group P < 0.001, between-group P > 0.05). Comparing
with each other, nicotinamide and clindamycin gels were significantly more
efficacious in oily and non-oily skin types, respectively. No major side effect
was encountered by any patient. Skin type is a significant factor in choosing
between topical nicotinamide and clindamycin in patients with acne vulgaris.
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