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Comparison of treatment effect of sodium valproate, propranolol and tricyclic antidepressants in migraine.

Author(s): Keyvan G, Abolfazl MB

Affiliation(s): Faculty of Medical, Arak University of Medical Sciences, Arak, Iran.

Publication date & source: 2009-08-01, Pak J Biol Sci., 12(15):1098-101.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

This study was conducted to evaluate and compare the efficacy and treatment effect of sodium valprovate with propranolol and tricyclic antidepressive drugs. This piece is a rarandomized clinical trial conducted on 126 migraine patients admitted to brain and nerves clinic in Arak, Iran. Patients were divided in two groups then randomized to study treatments. Data were gathered using a checklist and a complete examination. They were analyzed by Chi square and exact test. In patients with normal and abnormal encephalogram the effectiveness rate of two treatments were 35, 61.9, 95.6 and 28.6%, respectively. This difference between two treatments was statistically significant (p<0.001). But didn't observe significant differences between two sex groups (p>0.05). For treatment and control of the migraine, in patients with normal encephalogram, propranolol with tricyclic antidepressive drugs advised and for abnormal encephalogram sodium valprovate can be the better treatment for management and reduction of headache attacks.

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