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0.05% clobetasol 17-propionate cream and ointment but not the corresponding 0.1% triamcinolone acetonide preparations increase skin surface roughness: a possible dissociation of unwanted epidermal and dermal effects.

Author(s): Kerscher MJ, Korting HC, Mehringer L, Matzig R

Affiliation(s): Dermatologische Klinik, Ludwig-Maximilians-Universitat, Munchen, Deutschland.

Publication date & source: 1996, Skin Pharmacol., 9(2):120-3.

Publication type: Clinical Trial; Randomized Controlled Trial

Repeated open application of clobetasol 17-propionate cream and ointment to normal skin over a period of 6 weeks induced an increase in skin surface roughness as assessed by profilometry (p < 0.05), while 6 weeks' application of triamcinolone acetonide cream and ointment did not. The increase in skin roughness with clobetasol 17-propionate cream turned out to be greater than with ointment containing identical amounts of clobetasol 17-propionate (p < 0.05). A clear-cut correlation between increase of skin surface roughness and skin thickness as assessed by high-frequency ultrasound could be demonstrated only with clobetasol 17-propionate cream and ointment.

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