Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs.

Author(s): Kern ER, Palmer J, Szczech G, Painter G, Hostetler KY

Affiliation(s): University of Alabama School of Medicine, Birmingham 35294-2170, USA.

Publication date & source: 2000-01, Nucleosides Nucleotides Nucleic Acids., 19(1-2):501-13.

Publication type:

The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective.