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No effect of six weeks of treatment with escitalopram on mood in healthy volunteers--irrespective of genotype for the promoter of the serotonin transporter.

Author(s): Kellner M, Demiralay C, Muhtz C, Husemann J, Kolsch W, Hiemke C, Yassouridis A, Wiedemann K

Affiliation(s): Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany. kellner@uke.uni-hamburg.de

Publication date & source: 2008-12-15, Psychiatry Res., 161(3):339-43. Epub 2008 Oct 29.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Data on emotional effects of chronic antidepressants in normal subjects are scarce and contradictory. Thirty healthy men were given 10 mg/day of escitalopram for 6 weeks in a double-blind, placebo-controlled, within-subject cross-over study. No significant effect on negative affect, positive affect, or state anxiety was detected, irrespective of serotonin transporter gene-linked polymorphism.

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