Steady-state pharmacokinetics of micafungin and voriconazole after separate and concomitant dosing in healthy adults.

Author(s): Keirns J, Sawamoto T, Holum M, Buell D, Wisemandle W, Alak A

Affiliation(s): Astellas Pharma US, Inc., 3 Parkway North, Deerfield, IL 60015-2548, USA. jim.keirns@us.astellas.com

Publication date & source: 2007-02, Antimicrob Agents Chemother., 51(2):787-90. Epub 2006 Nov 20.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters were within the 80%-to-125% limits, indicating an absence of drug interaction.