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Oral contraceptives alone and with spironolactone increase sCD40 ligand in PCOS patients.

Author(s): Kebapcilar L, Bilgir O, Taner CE, Kebapcilar AG, Kozaci DL, Alacacioglu A, Yildiz Y, Yuksel A, Sari I

Affiliation(s): Department of Internal Medicine, Bozyaka Training and Research Hospital, Izmir, Turkey. leventkebapcilar@yahoo.com

Publication date & source: 2010-03, Arch Gynecol Obstet., 281(3):539-43. Epub 2009 Aug 5.

Publication type: Randomized Controlled Trial

BACKGROUND: The present study was designed to determine the effect of oral contraceptives (OCP) and OCP plus spironolactone (Sp) on plasma soluble CD40L levels in polycystic ovary syndrome (PCOS) patients. METHODS: Fifty-six women with PCOS were randomized into two treatment protocols: ethinylestradiol + cyproterone acetate (2 mg, EE/CA; n = 28), and EE/CA with spironolactone (Sp; n = 28). Plasma sCD40L levels were measured before and after a 3-month treatment. RESULTS: Before the initiation of treatment, the sCD40L levels were not significantly different between the groups [EE/CA (1.33 ng/mL) vs. EE/CA + Sp (1.23 ng/mL); P > 0.05]. In the post-treatment period, sCD40L concentrations were increased compared with pre-treatment values in the EE/CA and EE/CA + Sp groups (1.33 vs. 2.70 ng/mL, P = 0.011; and 1.23 vs. 2.41 ng/mL, P = 0.017; respectively). CONCLUSION: Increased plasma concentrations of sCD40L are associated with OCP and OCP + Sp treatment regimens in PCOS patients.

Page last updated: 2010-10-05

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