[An interesting change of E-selectin in cimetidine administration during anticancer drug use]

Author(s): Kawase J, Kobayashi K, Imaeda Y, Umemoto S, Matsumoto S

Affiliation(s): Dept. of Surgery, 2nd Teaching Hospital, Fujita Health University.

Publication date & source: 2005-10, Gan To Kagaku Ryoho., 32(11):1578-9.

Publication type: Randomized Controlled Trial

E-selectin is an adhesion molecule developed as an important material for hematogenous metastasis of cancer cells on vascular endothelial cells. It is expected that if we can restrain a manifestation of E-selectin then hematogenous metastasis can be restrained. We divided gastric cancer and the colorectal cancer patients, who performed chemotherapy, into two groups of cimetidine administrated group and a non-administration group, and reviewed whether cimetidine inhibited an expression of E-selectin on vascular endothelial cells by measuring E-selectin in plasma. We experienced one example that showed an interesting change of E-selectin and the quantity of E-selectin in plasma fell during the cimetidine dosage. However, we report that E-selectin has risen after the cimetidine dosage was cancelled in the cimetidine administrated group.