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A double-blind trial of treatment of seborrhoeic dermatitis with 2% ketoconazole cream compared with 1% hydrocortisone cream.

Author(s): Katsambas A, Antoniou C, Frangouli E, Avgerinou G, Michailidis D, Stratigos J

Affiliation(s): A. Sygros Hospital for Diseases of the Skin, University of Athens, Greece.

Publication date & source: 1989-09, Br J Dermatol., 121(3):353-7.

Publication type: Clinical Trial; Randomized Controlled Trial

Fifty patients with seborrhoeic dermatitis were treated with 2% ketoconazole cream (n = 24) or with 1% hydrocortisone cream (n = 26) for 4 weeks in a double-blind comparative study. These twice daily applications resulted in 87.2% symptomatic improvement for hydrocortisone vs. 81.6% for ketoconazole. The number of P. ovale yeasts was significantly reduced after the application of ketoconazole compared with hydrocortisone. The incidence of side-effects was low in both groups.

Page last updated: 2006-01-31

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