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Comparison of effectiveness of carvedilol versus bisoprolol for maintenance of sinus rhythm after cardioversion of persistent atrial fibrillation.

Author(s): Katritsis DG, Panagiotakos DB, Karvouni E, Giazitzoglou E, Korovesis S, Paxinos G, Anagnostopoulos CE, Camm AJ

Affiliation(s): Department of Cardiology, Athens Euroclinic, Athens, Greece. dkatritsis@euroclinic.gr

Publication date & source: 2003-11-01, Am J Cardiol., 92(9):1116-9.

Publication type: Clinical Trial; Randomized Controlled Trial

Ninety patients who underwent cardioversion of persistent atrial fibrillation (AF) were randomized to bisoprolol 5 to 10 mg once daily or carvedilol 12.5 to 25 mg twice daily. Using intention-to-treat analysis, 23 patients (46%) in the bisoprolol group and 17 patients (32%) in the carvedilol group relapsed into AF during the 1 year of total follow-up (p = 0.486). Patients treated with carvedilol had a 14% (hazard ratio 0.86) lower risk of relapse of AF compared with patients in the bisoprolol group, although results were statistically insignificant (p = 0.661) after controlling for patient age, gender, baseline heart rate, and left atrial diameter.

Page last updated: 2006-01-31

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