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Combination of calcipotriol and clobetasol propionate as a premixed ointment for the treatment of psoriasis.

Author(s): Katoh N, Kishimoto S

Affiliation(s): Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawara-machi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. nkatoh@koto.kpu-m.ac.jp

Publication date & source: 2003-07, Eur J Dermatol., 13(4):382-4.

Publication type: Clinical Trial; Randomized Controlled Trial

The treatment of psoriasis requires good compliance, efficacy and low toxicity because of its long-term course and wide distribution. The aim of the study was to compare the efficacy of a once daily application of calcipotriol alone or calcipotriol and a superpotent steroid in a premixed form in patients with psoriasis. The monotherapy group of 32 patients with stable plaque psoriasis received 0.005% calcipotriol alone once daily. The combination group of 29 patients was treated once per day with 0.004% calcipotriol/0.01% clobetasol propionate as a premixed ointment. Eruption score of truncal involvement was evaluated. The combination regimen was more efficacious than the monotherapy as evidenced by (1) more patients with at least 50% reduction in the eruption score after 2 weeks, (2) lower eruption score after 6 weeks and later, and (3) less adverse effects. The combined once-per-day application of 0.004% calcipotriol/0.01% clobetasol propionate as a premixed ointment is a promising regimen for psoriasis.

Page last updated: 2006-01-31

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