Monospecific antivenin therapy in Russell's viper bite.

Author(s): Karnchanachetanee C, Hanvivatvong O, Mahasandana S

Affiliation(s): Department of Medicine, Chao Phya Abhai Bhu Bejhr Hospital, Prachinburi, Thailand.

Publication date & source: 1994-06, J Med Assoc Thai., 77(6):293-7.

Publication type: Clinical Trial; Randomized Controlled Trial

Venom antigenemia was detected in 24 out of 30 Russell's viper bites. Those who suffered clinical bleeding (N = 14) had higher venom antigenemia than those who did not. The mean value of the amount of monospecific antivenin correcting blood incoagulability was 165 +/- 59.3 ml. Consequently, the recommended treatment is 60 ml of antivenin being administered intravenously at 6-hour intervals until blood coagulability is restored. There were no serious complications after antivenin administration. Renal complication (3 cases) was the major problem following this snake bite. One patient with clinical diagnosis of central nervous system bleeding died on admission.