Oral ketamine premedication can prevent emergence agitation in children after desflurane anaesthesia.

Author(s): Kararmaz A, Kaya S, Turhanoglu S, Ozyilmaz MA

Affiliation(s): Department of Anaesthesiology, Dicle University Hospital, Diyarbakir, Turkey. akararmaz@ixir.com

Publication date & source: 2004-06, Paediatr Anaesth., 14(6):477-82.

Publication type: Clinical Trial; Randomized Controlled Trial

BACKGROUND: The purpose of the present study was to determine whether oral ketamine premedication affected the incidence of emergence agitation in children. METHODS: Thirty minutes before induction of anaesthesia, 80 children who were undergoing adenotonsillectomy with or without bilateral myringotomy and insertion of tubes received either ketamine 6 mg.kg(-1) per oral in group K or sour cherry juice alone in group C. Anaesthesia was maintained with desflurane. Emergence and recovery times were recorded. Tramadol was used for postoperative analgesia. Fentanyl (1 microg.kg(-1)) was administered for the treatment of emergence agitation or severe pain that still continued after tramadol administration. Postoperative behaviour was evaluated using a 5-point agitation scale. RESULTS: The incidence of emergence agitation was 56% in group C, and 18% in group K (P = 0.001). There was no significant difference with respect to emergence times except from time to eye opening that was significantly longer in group K (P < 0.0001). CONCLUSION: Oral ketamine premedication reduced the incidence of postanaesthesia emergence agitation in children without delaying recovery.