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Estrogen plus progestin treatment: effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women.

Author(s): Karaflou M, Kaparos G, Rizos D, Creatsa M, Christodoulakos G, Lambrinoudaki I

Affiliation(s): Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece. mariakaraflou@yahoo.co.uk

Publication date & source: 2010-11, Fertil Steril., 94(6):2399-401. Epub 2010 May 20.

Publication type: Randomized Controlled Trial

One hundred healthy postmenopausal women were randomly assigned to receive 17beta-E2 1 mg/drospirenone 2 mg or 17beta-E2 1 mg/norethisterone acetate 0.5 mg for 6 months, and circulating soluble Fas, soluble Fas ligand, and cytochrome c were measured at baseline and at 6 months in 87 women who completed the study. Although cytochrome c levels were undetectable, circulating soluble Fas/soluble Fas ligand ratio decreased in both groups, suggesting a decrease in ligand-mediated apoptosis. Copyright (c) 2010. Published by Elsevier Inc.

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