Dose proportionality study of loperamide following oral administration of loperamide oxide.

Author(s): Kamali F, Adriaens L, Huang ML, Woestenborghs R, Emanuel M, Rawlins MD

Affiliation(s): Wolfson Unit of Clinical Pharamcology, The University, Newcastle upon Tyne, UK.

Publication date & source: 1992, Eur J Clin Pharmacol., 42(6):693-4.

Publication type: Clinical Trial; Randomized Controlled Trial

The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.