Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine,
calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive
toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized
clinical trial.
Author(s): Kakar A, Kakar K, Sreenivasan PK, DeVizio W, Kohli R.
Affiliation(s): Global Health Research Group, New Delhi, India.
Publication date & source: 2012, J Clin Dent. , 23(2):40-7
OBJECTIVE: This clinical study was designed to compare dentin hypersensitivity
relief among subjects who brushed their teeth with a new toothpaste containing
8.0% arginine, calcium carbonate, and 1000 ppm fluoride as sodium
monofluorophosphate (MFP) to subjects who brushed with a commercially available
dentifrice containing 2% potassium ion as potassium nitrate over an eight-week
period.
METHODS: Adult male and female subjects from the New Delhi, India area were
required to present two teeth that exhibited dentin hypersensitivity, both to
tactile stimulation using the Yeaple Probe and to air blast stimulation delivered
by a standard dental unit syringe. After an examination of the oral soft and hard
tissues, qualifying subjects were randomly assigned one of the study dentifrices
and a soft-bristled toothbrush, and were instructed to brush their teeth for one
minute, twice daily (morning and evening), using only the toothbrush and
dentifrice provided. No other oral hygiene practices were permitted over the
course of the study. After two, four, and eight weeks of product use, subjects
returned to the dental clinic for follow-up examinations of tactile and air blast
sensitivity of the baseline-designated hypersensitive teeth. Examinations of the
oral soft and hard tissues were also performed at these follow-up visits.
RESULTS: Subjects who brushed with the new dentifrice containing 8.0% arginine,
calcium carbonate, and 1000 ppm MFP exhibited statistically significant
reductions (p < 0.05) in dentin hypersensitivity in response to tactile (36.2%,
33.1%, and 29.7%) and air blast (16.4%, 31.1%, 58.8%) stimuli when compared to
the subjects who brushed with the 2% potassium ion as potassium nitrate
dentifrice after two, four, and eight weeks, respectively.
CONCLUSION: The use ofa new dentifrice containing 8.0% arginine, calcium
carbonate, and 1000 ppm MFP provides greater efficacy in reducing dentin
hypersensitivity when compared to a dentifrice containing 2% potassium ion, as
potassium nitrate, after two, four, and eight weeks of product use.
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