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Calcific uremic arteriolopathy treated with cinacalcet, paricalcitol, and autologous growth factors.

Author(s): Kakagia D, Kriki P, Thodis E, Roumeliotis A, Vargemezis V

Affiliation(s): Department of Plastic and Reconstructive Surgery, Democritus University Hospital, Alexandrouplois, Greece. despoinakakagia@yahoo.com

Publication date & source: 2011-03, J Cutan Med Surg., 15(2):121-4.

Publication type: Case Reports

BACKGROUND: Calcific uremic arteriolopathy is an uncommon cutaneous ischemic necrotizing disease, most commonly associated with renal disease and hyperparathyroidism, bearing a high mortality rate. OBJECTIVE AND METHOD: A case of a 57-year-old female renal patient with hyperparathyroidism who was successfully treated with combined paricalcitol and cinacalcet systemically, while autologous growth factors were locally applied, is herein presented. RESULT AND CONCLUSION: The combination of cinacalcet and paricalcitol is a reliable alternative to parathyroidectomy in patients with calcific uremic arteriolopathy and hyperparathyroidism. Meticulous debridement of necrotic tissues is essential and application of autologous growth factors promotes healing.

Page last updated: 2011-12-09

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