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Five-day versus ten-day treatment of acute otitis media with cefprozil.

Author(s): Kafetzis DA, Astra H, Mitropoulos L

Affiliation(s): Second Department of Paediatries, P & A Kyriakou Children's Hospital, University of Athens, Athens 11527, Greece.

Publication date & source: 1997-04, Eur J Clin Microbiol Infect Dis., 16(4):283-6.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

A randomized comparative clinical trial was conducted to investigate the possibility of decreasing the duration of treatment of acute otitis media by comparing the clinical outcome and safety of a five-day and a ten-day course of cefprozil. A total of 708 pediatric patients were enrolled in the study, 560 of whom were evaluable for efficacy. Cefprozil was found to be completely effective in 87.1% of cases after five days of treatment, and in 91.2% after ten days of treatment. Of 19 patients with three or more previous episodes of acute otitis media, ten patients in the ten-day treatment group had a 100% cure rate, while in the five-day group four experienced cure, three improvement, and two failure. A five-day course of treatment with cefprozil can be recommended only if children have no history of recurrent acute otitis media.

Page last updated: 2006-01-31

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