[Practical applications of recombinant alpha-1-antitrypsin in medicine].
Author(s): Kabzinski J, Kedziora J, Majsterek I
Affiliation(s): The University of Humanities and Economics in Lodz, Poland.
Publication date & source: 2010-12, Pol Merkur Lekarski., 29(174):345-50.
Publication type: Editorial; English Abstract
Alpha-1-antytripsin deficiency, human plasma protein belonging to serine proteinase inhibitor, is the underlying reason for causing such diseases as liver cirrhosis or pulmonary emphysema. It has been proven that alpha-1-antytripsin deficiency can be treated with replacement therapy of this protein. Because of the risks associated with the administration to patients with deficiency of alpha-1-antytrypsyny protein fractionated from human plasma, the methods of gaining recombinant alpha-1-antytripsin are still being developed. Methods for the production of alpha-1-antytripsin synthesized using transgenic animals can achieve high performance while maintaining a fully functional protein structure. Obtained in this way, alpha-1-antitrypsin gives hope for the use of replacement therapy on a large scale.
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