A comparison of circulating hormone levels in postmenopausal women receiving hormone replacement therapy.

Author(s): Jurgens RW Jr, Downey LJ, Abernethy WD, Cutler NR, Conrad J

Affiliation(s): Clinical Research Group, Solvay Pharmaceuticals, Marietta, GA 30062.

Publication date & source: 1992-08, Am J Obstet Gynecol., 167(2):459-60.

Publication type: Clinical Trial; Randomized Controlled Trial

Seventeen postmenopausal subjects were randomized into this comparative study of esterified estrogen 0.625 mg (Estratab), esterified estrogen 0.625 mg plus 1.25 mg methyltestosterone (Estratest H.S.), or conjugated estrogen 0.625 mg (Premarin). Sixteen subjects completed the study in which plasma hormone concentrations of estrone and estradiol were assessed at various time points. There were no significant differences among the treatment groups.