Is intra-articular multimodal drug injection effective in pain management after
total knee arthroplasty? A randomized, double-blinded, prospective study.
Author(s): Joo JH, Park JW, Kim JS, Kim YH.
Affiliation(s): Joint Replacement Center of Korea, Ewha Womans University School of Medicine,
Seoul, South Korea.
Publication date & source: 2011, J Arthroplasty. , 26(7):1095-9
We performed a prospective, double-blinded, randomized, and controlled study to
assess the clinical efficacy and safety of intra-articular multimodal drug
injection after total knee arthroplasty. Two hundred eighty-six patients
undergoing simultaneous bilateral total knee arthroplasty were randomized to
receive the injection of multimodal drugs in one knee and normal saline solution
as a placebo in the contralateral knee. All patients received patient-controlled
analgesia for 48 hours after surgery, followed by standard analgesia. Visual
analog scores for pain during activity and rest and for patient satisfaction were
recorded. The range of motion and blood loss were also recorded. Intraoperative
intra-articular injection of multimodal drugs into the knee did not improve
patient pain and satisfaction, range of motion, or blood loss compared with the
placebo control.
|