The effects of cilazapril alone and in combination with frusemide in healthy subjects.

Author(s): Johnston GD, Passmore AP

Affiliation(s): Department of Therapeutics and Pharmacology, Queen's University, Belfast.

Publication date & source: 1989, Br J Clin Pharmacol., 27 Suppl 2:235S-242S.

Publication type: Clinical Trial; Controlled Clinical Trial; Randomized Controlled Trial

1. In a fourway double-blind placebo controlled study, the effects of cilazapril, a new angiotensin converting enzyme inhibitor, on renal function and the responses to intravenous frusemide were studied in a group of twelve salt depleted male volunteers. 2. Cilazapril produced an increase in effective renal plasma flow and urinary output of prostaglandin E2 metabolite (PGE2-M) but no effect on sodium, potassium or water excretion. 3. Pretreatment with cilazapril antagonised the effects of frusemide on glomerular filtration, PGE2-M and sodium excretion.