Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced reduction in hunger.
Author(s): Johnson BA, Ait-Daoud N, Bordnick PS
Affiliation(s): Division of Alcohol and Drug Addiction, University of Texas, Health Science Center at San Antonio, USA. email@example.com
Publication date & source: 1999-10, Prog Neuropsychopharmacol Biol Psychiatry., 23(7):1227-34.
Publication type: Clinical Trial; Randomized Controlled Trial
1. The authors studied the effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced changes in somatic and psychological perceptions of hunger state using a placebo-controlled, double-blind, Latin Square, cross-over design in 18 healthy volunteers. 2. D-methamphetamine significantly decreased these subjective ratings of hunger, presumably by increasing monoaminergic turnover. 3. Effects on hunger are hypothesized to be mediated by norepinephrine primarily, while dopamine plays only a modest role. Isradipine alone, an inhibitor of dopamine release, had no significant effect on the hunger measures. Additionally, isradipine pretreatment did not significantly alter d-methamphetamine's anorexic effects. 4. Isradipine may, therefore, not significantly modify the control of hunger in humans.