[The therapeutic effect of Anluohuaxian capsule combined with adefovir dipivoxil
on patients with chronic hepatitis B and influence on hepatic histology]. [Article in Chinese]
Author(s): Jiang YF, Ma J, He B, Li NP, Tang W, Gong GZ.
Affiliation(s): Central South University, Changsha, China.
Publication date & source: 2012, Zhonghua Gan Zang Bing Za Zhi. , 20(5):344-7
To observe the efficacy of adefovir dipivoxil(ADV) in combination with
Anluohuaxian capsule in the treatment of chronic hepatitis B (CHB)
patients.METHODS: 72 cases with CHB were randomly divided into two groups. 36
cases of treatment group were given ADV combined with Anluohuaxian capsule for 48
weeks. 36 cases of control group were given ADV. The levels of serum ALT, AST,
Alb, TBil, HA, LN, CIV, HBV DNA and hepatic tissue were compared before and after
being treated.
RESULTS: After 48 weeks treatment,the liver function, serum fibrosis index and
histology of treatment group and control group all have improved. After
treatment, the two groups in the levels of ALT(t=0.746, P=0.342), AST (t=0.369,
P=0.713), TBil (t=0.146, P=0.684), Alb(t=0.148, P=0.883), liver tissue
inflammation mobility scoring (t=1.666, P=0.100) and HBV DNA negative rate
(x2=0.141, P=0.708) were no evident difference.The level of HA, LN, CIV were
significantly lower in treatment group(101.58+/-30.11, 147.89+/-41.72,
38.75+/-9.50) compared with control group(182.25+/-117.59, 181.50+/-56.96,
74.92+/-31.14) (P less than 0.05). After the treatment, the liver tissue fibrosis
scoring was significantly lower in treatment group (10.61+/-2.37) compared with
before the treatment (12.28+/-3.16) (P less than 0.05).There was no difference
found between after the treatment (11.36+/-2.93) and before the treatment
(12.17+/-3.01) in control group (P more than 0.05).
CONCLUSIONS: The results show that the treatment with ADV in combination with
Anluohuaxian capsule can play promoting antifibrotic effect and significant
improved liver histology of chronic hepatitis B patients.
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