Influence of low-dose daily cisplatin on the distant metastasis-free survival of patients with locally advanced nonmetastatic head and neck cancer treated with radiation therapy.

Author(s): Jeremic B, Milicic B

Affiliation(s): Department of Oncology, University Hospital, Kragujevac, Serbia. B.Jeremic@iaea.org

Publication date & source: 2008-05, Radiother Oncol., 87(2):201-3. Epub 2008 Jan 18.

Publication type: Clinical Trial, Phase III; Randomized Controlled Trial

We investigated the impact of low dose daily cisplatin on distant metastasis-free survival (DMFS) in locally advanced head and neck cancer treated with hyperfractionated radiotherapy (77Gy in 70 fractions in 35 treatment days). In locally controlled tumors cisplatin led to better DMFS (p=0.0272); Cisplatin may have acted independently of micrometastasis in locally advanced H&N cancer.