Chelation of cadmium by combining deferasirox and deferiprone in rats.
Author(s): Jamilaldin Fatemi S, Saljooghi AS, Balooch FD, Iranmanesh M, Golbafan MR
Affiliation(s): Chemistry Department, Shahid Bahonar University of Kerman, Kerman, Iran. email@example.com
Publication date & source: 2011-05, Toxicol Ind Health., 27(4):371-7. Epub 2011 Jan 18.
The present research aimed to characterize the potential efficiency of two chelators after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing cadmium from the body was considered. In this way, two known chelators deferasirox and deferiprone (L(1)) were chosen and tested in the acute rat model. Two chelators were given orally as a single or combined therapy for the period of a week. Cadmium and iron concentrations in various tissues were determined by graphite furnace and flame atomic absorption spectrometry methods, respectively. The combined chelation therapy results show that Deferasirox and L(1) are able to remove cadmium ions from the body while iron concentration returned to the normal level and symptoms are also decreased.