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Comparative efficacy of narrow-band ultraviolet B phototherapy alone and its combination with topical 8-methoxypsoralen in psoriasis.

Author(s): Jain VK, Jangra S, Aggarwal K

Affiliation(s): Department of Dermatology, Venereology and Leprology, Pt. B. D. Sharma University of Health Sciences, Rohtak, Haryana, India. dr_vkjain2002@yahoo.co.in

Publication date & source: 2010-11, Indian J Dermatol Venereol Leprol., 76(6):666-70.

Publication type: Comparative Study

BACKGROUND: Very few studies using the combination of topical 8-methoxypsoralen (8-MOP) and narrow-band ultraviolet B (NBUVB) have been performed, especially in Indian patients. A combination of oral psoralen with NBUVB has been shown to have a superior efficacy as compared with NBUVB alone in psoriasis. AIMS: Comparison of the efficacy of topical psoralen NBUVB (combination) versus NBUVB alone in psoriasis. METHODS: Thirty patients with plaque psoriasis were taken up for the study and NBUVB phototherapy was given twice weekly. The target lesions on one side were treated with 0.1% topical 8-MOP 15 min before the irradiation. The treatment period was 12 weeks or 24 exposures. RESULTS: The number of treatment sessions and cumulative NBUVB doses were lower in the combination therapy as compared with NBUVB monotherapy, although the differences were not statistically significant. CONCLUSION: To conclude, topical 8-MOP enhances the therapeutic effects of NBUVB therapy without increasing the incidence of adverse effects.

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