A double-blind, randomized, comparative trial of itraconazole versus terbinafine for 2 weeks in tinea capitis.

Author(s): Jahangir M, Hussain I, Ul Hasan M, Haroon TS

Affiliation(s): Department of Dermatology, King Edward Medical College/Mayo Hospital, Lahore, Pakistan.dderma@paknet1.ptc.pk

Publication date & source: 1998-10, Br J Dermatol., 139(4):672-4.

Publication type: Clinical Trial; Randomized Controlled Trial

In this randomized, double-blind study, the efficacy and safety of oral itraconazole (n = 28) and terbinafine (n = 27), each given for 2 weeks, was compared in patients with tinea capitis. Trichophyton violaceum was the major pathogen in both groups (82.1% and 88.9%, respectively). The final evaluation at week 12 showed a cure rate of 85.7% and 77.8%, respectively (P > 0.05). Adverse events noted were mild and did not warrant discontinuation of therapy.