A comparison of mebendazole and albendazole in treating children with Trichuris trichiura infection in Durban, South Africa.

Author(s): Jackson TF, Epstein SR, Gouws E, Cheetham RF

Affiliation(s): Medical Research Council, Durban.

Publication date & source: 1998-07, S Afr Med J., 88(7):880-3.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To compare the efficacy of mebendazole 500 mg and albendazole 400 mg single-dose treatments of Trichuris trichiura infection in children in the Durban area of KwaZuluNatal, South Africa. DESIGN: A single-blind randomised trial in children with a documented moderate infection of T. trichiura. Ova were counted in stool specimens before and 10 days after treatment by the formal-ether concentration method. SETTING: Two shelters for abandoned and orphaned children in Durban. PARTICIPANTS: Ninety-six children aged between 2 and 12 years. OUTCOME MEASURES: The number of children who showed reduced T. trichiura ova counts after the treatments, and reductions in ova counts, both expressed as percentages. Statistical analysis using the Wilcoxon 2-sample test and the chi-square test. RESULTS: Eighty-two children completed the trial; 42 received mebendazole and 40 albendazole. Of the mebendazole group 85% showed a reduction in T. trichiura ova count, compared with 75% of children who received albendazole. Mebendazole treatment was associated with a median percentage reduction in ova count of 72.2%, which significantly exceeded the 44.1% reduction after albendazole (P = 0.024). CONCLUSION: The mebendazole 500 mg single-dose therapy was more efficacious than the albendazole 400 mg single-dose therapy in treating T. trichiura infection in these children.