Antibiotic prophylaxis for transrectal biopsy of the prostate: a prospective randomized study of the prophylactic use of single dose oral fluoroquinolone versus trimethoprim-sulfamethoxazole.

Author(s): Isen K, Kupeli B, Sinik Z, Sozen S, Bozkirli I

Affiliation(s): Department of Urology, Gazi University, Faculty of Medicine, Ankara, Turkey.

Publication date & source: 1999, Int Urol Nephrol., 31(4):491-5.

Publication type: Clinical Trial; Randomized Controlled Trial

We investigated the efficacy of prophylactic use of single dose oral ofloxacin and trimethoprim-sulfamethoxazole regimens for transrectal prostate biopsy in 110 men. In the ofloxacin, trimethoprim-sulfamethoxazole and control groups, urinary infection was found in 2 (4.76%), 3 (6.66%) and 6 (26.08%) patients, respectively. Both of these antibiotic regimens produced a statistically significant reduction in urinary infection (p<0.02, p<0.05). Our study indicates that single dose fluoroquinolone or trimethoprim-sulfamethoxazole prophylaxis seems to be effective, practical and economical.