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The safety of diclofenac for the management and treatment of actinic keratoses.

Author(s): Iraji F, Siadat AH, Asilian A, Enshaieh S, Shahmoradi Z

Affiliation(s): Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran. iraji@med.mui.ac.ir

Publication date & source: 2008-03, Expert Opin Drug Saf., 7(2):167-72.

Publication type: Review

BACKGROUND: Actinic keratoses (AKs), defined as carcinoma in situ of squamous carcinoma, is usually induced by excessive sun exposure. The efficacy of 3% diclofenac in 2.5% hyaluronic acid gel for treatment of AKs has been documented in a few studies. OBJECTIVE: Is diclofenac safe and effective for the management and treatment of AKs? METHOD: All the papers that were cited in Medline and ISI Web of Science are included in this study. RESULTS/CONCLUSION: The use of diclofenac is associated with a few side effects, which include pruritus, rashes, dry skin, and scaling. These side effects are usually minimal and tolerable; therefore, this topical medication is suggested as the first line of treatment for AKs.

Page last updated: 2008-06-22

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