Efficacy and tolerability of a single-pill combination of amlodipine/valsartan in Asian hypertensive patients not adequately controlled with valsartan monotherapy.
Author(s): Huang J, Sun NL, Hao YM, Zhu JR, Tu Y, Curt V, Zhang Y
Affiliation(s): The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Publication date & source: 2011, Clin Exp Hypertens., 33(3):179-86. Epub 2011 Apr 5.
Publication type: Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
This randomized, double-blind study evaluated efficacy of a single-pill combination of amlodipine/valsartan (Aml/Val) in Asian patients with hypertension not responding to Val 80 mg. Patients with mean sitting diastolic blood pressure (DBP) >/=90-</=110 mmHg were randomized to Aml/Val 5/80, Val 80, or Val 160 mg for 8 weeks. At week-8 endpoint, significantly greater reductions in BP were seen with Aml/Val 5/80 mg than valsartan monotherapies (p < 0.0001). The BP control was greater with Aml/Val 5/80 (70.5%) than Val (44.1-58.6%) monotherapies. The combination was well tolerated. In conclusion, single-pill combination with Aml/Val provided significant additional BP reduction and control in hypertensive patients not responding to Val 80 mg.