Fluocinolone acetonide implant (Retisert) for chronic cystoid macular edema in two patients with AIDS and a history of cytomegalovirus retinitis.
Author(s): Hu J, Coassin M, Stewart JM
Affiliation(s): University of California, San Francisco, Department of Ophthalmology, San Francisco, California 94143-0730, USA.
Publication date & source: 2011-06, Ocul Immunol Inflamm., 19(3):206-9.
Publication type: Case Reports; Research Support, Non-U.S. Gov't
PURPOSE: To report the authors' experience using fluocinolone acetonide (Retisert) to treat cystoid macular edema (CME) resulting from immune recovery uveitis (IRU) in 2 acquired immunodeficiency syndrome (AIDS) patients with a history of cytomegalovirus (CMV) retinitis. Design: Interventional case series. METHODS: Medical records were reviewed of 2 patients who received Retisert implantation in 3 eyes for IRU-associated inflammation and CME. Suppression of CMV disease was achieved with oral medication in one patient and with simultaneous implantation of a ganciclovir implant in the other patient. RESULTS: After Retisert implantation in 3 eyes in AIDS patients on HAART, improvement in CME was seen in 2 eyes. No CMV reactivation was detected during the several-month follow-up period. CONCLUSIONS: Retisert may be an effective treatment for CME in AIDS patients with IRU reactivation and a history of CMV retinitis.
|